Figure 9
Animals exposed to 1.0 Gy at E11 display persistent changes in brain anatomy. (A) Representative anatomical 3D T2-weighted MR images of control animals and mice irradiated with 1.0 Gy at E11 at 1, 4 and 20 weeks after birth. (B) Quantitative analysis of these MR images demonstrated that the cortical thickness of the irradiated mice was mildly decreased, although not statistically significant. (C) At similar time points, these animals showed dilated ventricles, which was significant in 40-week-old animals. Data are presented as mean ± SEM. *P < 0.05 for comparison with controls. The number of animals used per test is indicated in the graphs (N).