Violence: heightened brain attentional network response is selectively muted in Down syndrome

Table 2 Clusters showing significant difference in activation between control and Down syndrome groups. All clusters showed higher activation in control sample. q values show cluster-corrected false discovery rate. T-statistics show peak voxelwise results

Contrast	Region	MNI coordinates	Cluster q-value (FDR)	Number of voxels
Control > DS
Antagonist on screen	Left intraparietal sulcus	(−21 − 55 67)	0.00000009	284
Antagonist on screen	Right frontal eye field	(18 –10 55)	0.000002	383
Antagonist on screen	Left frontal eye field	(−24 − 10 61)	0.008	80
Antagonist on screen	Left middle temporal	(−36 − 64 4)	0.000009	230
Antagonist on screen	Left parahippocampal	(−24 − 22 − 23)	0.011	66
Antagonist on screen	Left middle occipital	(−48 − 82 1)	0.016	57
Antagonist on screen	Left cerebellum	(−24 − 61 − 17)	0.008	76
Antagonist on screen	Right superior occipital	(18 − 91 34)	0.038	43
Antagonist on screen	Left cerebellum	(−12 − 73 − 47)	0.008	74
Antagonist on screen	Right supramarginal	(57 − 28 31)	0.06	34
Antagonist on screen	Right intraparietal sulcus	(18 − 61 61)	0.045	39
Auditory	Left superior temporal	(63 − 16 4)	0.001	117
Visual	Bilateral occipital	(18 − 76 37)	3.7 × 10⁻²⁸	2428
Violence	Left intraparietal sulcus	(−18 − 55 73)	0.000008	229
Violence	Left posterior insula	(−36 − 13 1)	0.04	44
Violence	Left supramarginal	(−54 − 31 31)	0.05	33
Violence	Left frontal eye field	(−27 − 7 55)	0.04	43
Violence	Left middle temporal	(−39 − 58 1)	0.04	40
DS > control
Violence	Right superior temporal	(63 − 19 4)	0.0001	153
Violence	Left superior temporal	(−57 − 40 4)	0.01	54

ISSN: 1866-1955