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Fig. 1 | Journal of Neurodevelopmental Disorders

Fig. 1

From: Comparative mapping of the 22q11.2 deletion region and the potential of simple model organisms

Fig. 1

Genetic landscape of the human 22q11.2 region. The typical ~2.5-Mb 22q11.2DS deletion spans 90 RefSeq genes (see text for details). Region breakpoints are mediated by four chromosome specific low-copy repeats (LCRA-D; approximate locations shown). Gene expression, indicated by a green circled check mark, was established using The Human Brain Transcriptome. Data for decreased expression with hemizygosity were collated from experimentally demonstrated [24, 2833] reductions in gene expression in blood cells from patients with 22q11.2DS. Gene names within a rectangle denote the 17 genes conserved across the mouse, zebrafish, fruit fly, and worm

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