Table 1 Demographic information of MPS III participants
Participant ID | Sex | Age (years) | MPS III subtype | Ethnicity | Current medication/intervention (effectivenessa) | Previous sleep intervention (effectivenessa) |
|---|---|---|---|---|---|---|
MPS1 | Male | 2 | B | Pakistani | None | None |
MPS2 | Male | 4 | A | White Polish | None | None |
MPS3 | Male | 5 | B | White British | None | Behavioural advice (parents had already tried techniques) |
MPS4 | Male | 10 | B | Pakistani | Melatoninb (good for settling) Loperamide | Herbal medicine (no effect after first week) |
MPS5 | Female | 10 | B | Pakistani | Walking (helpful) Risperidone (no effect) | None |
MPS6 | Female | 11 | A | White British | Gonapeptyl | None |
MPS7 | Male | 14 | A | White British | Chloral hydrate, zopiclone (short-term effects only), levetiracetam, ibuprofen, hyoscine | Melatonin (short-term effect only) Behavioural techniques (no effect) |
MPS8 | Female | 15 | A | White British | Zopiclone, clonazepam, midazolam, sodium valproate, Senokot, Movicol, omeprazole, glycopyrrolate, morphine, paracetamol | Melatonin (no effect) Temazepam (initial effect but discontinued due to distress/tearfulness) |