Skip to main content

Table 4 Anxiety scale relationship with MECP2 mutation severity

From: Anxiety-like behavior in Rett syndrome: characteristics and assessment by anxiety scales

  

Mild (n = 26)

Severe (n = 46)

Mutation differences

 

N

Median

SD

Median

SD

aMann-Whitney U

aAsymp. sig (two-tailed)

CSS

51

18.00

5.47

22.00

5.54

175.00*

0.009

RSBQ

       

Fear/anxiety

72

5.00

2.11

4.00

2.01

504.50

0.267

ADAMS

       

Social avoidance

72

4.00

3.29

4.00

3.69

515.50

0.330

General anxiety

71

7.00

4.32

5.00

4.80

377.00

0.013

ABC-C

       

Lethargy/social withdrawal

47

9.50

6.46

6.50

4.47

208.00

0.207

Social avoidance

47

1.50

2.79

0.00

1.34

208.50

0.179

  1. In bold, significant and trend-level p values
  2. *Adjusted for multiple [5] comparisons (excluding CSS) with Bonferroni corrections for the five anxiety-related measures, adjusted p = 0.01
  3. aGrouping mild vs. severe MECP2 mutation