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Fig. 7 | Journal of Neurodevelopmental Disorders

Fig. 7

From: Complete or partial reduction of the Met receptor tyrosine kinase in distinct circuits differentially impacts mouse behavior

Fig. 7

Theoretical model of Met gene dose effect on behavioral disruption. Our data indicate that intermediate expression of Met (Met fx/+/Nestin cre Het) resulted in significant behavioral deficits while the absence of Met (Met fx/fx/Nestin cre KO) only sometimes impacted behavior. The model suggests an inverse U-shaped model of atypical behavior such that an absence of Met can lead to compensatory changes in brain development. The model proposes a threshold of Met gene dosage for a behavior deficit and a second threshold of Met gene dosage that is permissive for compensatory mechanisms resulting in typical behavior

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