Skip to main content

Table 1 Behavioral characterization of WT and Metfx/fx/Emx1cre KO mice

From: Complete or partial reduction of the Met receptor tyrosine kinase in distinct circuits differentially impacts mouse behavior

  WT Metfx/fx/Emx1cre KO F or t Statistic p value
Activity chamber     
    Genotype, F (1, 51) = 12.26 p < 0.05
Total distance traveled(cm) 3317.67 ± 218.98 2339.74 ± 175.11 Time, F (5, 255) = 4.308 p < 0.001
    Interaction, F (5, 255) = 3.184 p < 0.01
Steady speed rotarod     
    Genotype, F (1, 52) = 4.249 p < 0.05
Average latency to fall(sec) 20.0185 ± 2.58 28.481 ± 3.19 Trial, F (9, 468) = 18.99 p < 0.0001
    Interaction, F (9, 468) = 1.063 p > 0.05
Accelerating rotarod     
    Genotype, F (1, 12) = 0.017 p > 0.05
Average latency to fall(sec) 151.43 ± 19.82 148.10 ± 16.14 Trial, F (2, 24) = 15.35 p < 0.0001
    Interaction, F (2, 24) = 0.024 p > 0.05
T-maze     
% SA 54.701 ± 1.679 47.4956 ± 2.401 t 51 = 2.475 p < 0.05
% AAR 35.063 ± 1.554 38.576 ± 1.599 t 51 = −1.576 p > 0.05
% SAR 3.891 ± 0.666 5.301 ± 0.907 t 51 = −1.410 p > 0.05
#arm entries 35.852 ± 2.456 29.154 ± 1.859 t 51 = 2.162 p < 0.05
Marble burying (#) 7.100 ± 1.567 9.200 ± 1.756 t 18 = 0.8923 p > 0.05
EPM entries (#)     
    Genotype, F (1, 32) = 0.2539 p > 0.05
Closed arms 9.188 ± 1.697 8.882 ± 1.364 Arm entry, F (1, 32) = 65.93 p < 0.05
Open arms 1.706 ± 0.803 0.5882 ± 0.298 Interaction, F (1, 32) = 0.2081 p > 0.05
EPM arm duration (%)     
    Genotype, F (1, 32) = 0.3463 p > 0.05
Closed arms 88.882 ± 3.169 86.863 ± 5.017 Arm duration, F (1, 32) = 220.8 p < 0.0001
Open arms 4.3137 ± 1.505 3.000 ± 1.649 Interaction, F (1, 32) = 0.2508 p > 0.05
Sociability (sec)     
    Genotype, F (1, 52) = 1.463 p > 0.05
Side with mouse 312.897 ± 14.864 317.225 ± 11.721 Chamber side, F (1, 52) = 74.25 p < 0.05
Side with empty cup 185.271 ± 12.428 162.44 ± 11.885 Interaction, F (1, 52) = 0.6864 p > 0.05
Social novelty (sec)     
    Genotype, F (1, 52) = 0.001 p > 0.05
Familiar mouse side 227.609 ± 13.819 235.362 ± 17.602 Chamber side, F (1, 52) = 1.545 p > 0.05
Novel mouse side 259.723 ± 14.579 252.667 ± 14.533 Interaction, F (1, 52) = 0.1387 p > 0.05
Sociability (sec)     
    Genotype, F (1, 52) = 0.005652 p > 0.05
Cup with mouse 62.795 ± 4.653 60.152 ± 5.095 Cup, F (1, 52) = 214.6 p < 0.05
Empty cup 11.818 ± 1.606 12.645 ± 1.254 Interaction, F (1, 52) = 0.2665 p > 0.05
Social novelty (sec)     
    Genotype, F (1, 52) = 0.02144 p > 0.05
Cup with familiar mouse 23.087 ± 3.234 21.624 ± 2.801 Cup, F (1, 52) = 63.83 p < 0.05
Cup with novel mouse 46.756 ± 5.329 46.817 ± 4.221 Interaction, F (1, 52) = 0.06198 p > 0.05
Contextual fear (%)     
Baseline 0.04976 ± 0.0497 0.3007 ± 0.1955 Genotype, F (1, 31) = 0.6584 p > 0.05
Training 28.73 ± 3.2649 32.72 ± 2.6444 Trial, F (2, 62) = 110.5 p < 0.0001
Test 29.04 ± 3.2954 30.81 ± 3.4346 Interaction, F (2, 62) = 0.3224 p > 0.05