Fig. 5

Expression pattern of ER81. a Strong reactivity for ER81 in the layers 5/6 in normal controls. b No differences in perilesional cortex (PLx). c Increased amount of ER81 expressing neurons in the upper layers of the neocortex in FCD type IIb (arrows). d Strong reactivity in DNs of cortical tubers (arrows), however, the constitutive expression pattern in normal appearing-neurons remains intact. Scale bar in d equals 500 μm and applies also to a–c. SG supragranular layers, IG infragranular layers, Co control, PLx perilesional cortex, Tb cortical tuber; IIb FCD type IIb