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Table 1 Total cell counts

From: Specific pattern of maturation and differentiation in the formation of cortical tubers in tuberous sclerosis complex (TSC): evidence from layer-specific marker expression

Pathology

Location

Total neurons [median]

Dysmorphic neurons [median]

Total Tbr1+ cells [median (range)]

Total Satb2+ cells [median (range)]

Total Cux2+ cells [median (range)]

Total RORβ+ cells [median (range)

Total ER81+ cells [median (range)]

Tbr1+ cells per total neurons [%]

Satb2+ cells per total neurons [%]

Cux2+ cells per total neurons [%]

RORβ+ cells per total neurons [%]

ER81+ cells per total neurons [%]

Tuber

SG

399.50 (154.00–899.0)

96.00 (11.00–238.00)

41.00 (0.00–126.00)

63.00 (49.00–161.00)

43.00 (0.00–145.00)

88.00 (5.00–198)

161.00 (99.00–706.00)

8.00

19.00

13.00

23.00

48.00

 

IG

348.00 (180.00–739)

111.50 (4.00–204.00)

94.00 (0.00–178.00)

2.00 (0.00–136.00)

13.00 (0.00–112.00)

134.00 (3.00–165.00)

206 (96.00–565.00)

30.00

1.00

4.00

27.00

49.00

FCD IIb

SG

476.00 (439.00–799.00)

217.00 (175.00–275.00)

44.00 (13.00–103.00)

181.00

88.00 (0.00–173.00)

156.00 (15.00–200.00)

373.00 (175.00–799.00)

9.00

23.00

20.00

25.00

85.00

 

IG

523.00 (374.00–643.00)

192.00 (113.00–206.00)

61.00 (58.00–287.00)

204.00

76.00 (44.00–123.00)

166.00 (98.00–187.00)

231.00 (182.00–314.00)

12.00

32.00

12.00

26.00

49.00

PLx

SG

916.00 (682.00–2263.00)

0.00

176.00 (0.00–460.00)

193.00 (136.00–315.00)

345.00 (78.00–660.00)

121.00 (0.00–264.00)

227.00 (12.00–652.00)

16.00

19.00

37.00

10.00

27.00

 

IG

1000.00 (535.00–1242.00)

0.00

420.00 (246.00–662.00)

14.00 (9.00–215.00)

99.00 (12.00–276.00)

452.00 (120.00–688.00)

519.5 (169.00–987.00)

44.00

3.00

16.00

55.00

64.00

Control

SG

952.00 (299.00–1175.00)

0.00

14.50 (5.00–24.00)

548.00 (420.00–676.00)

367.00

49.00 (35.00–63.00)

65.50 (58.0–73.00)

0.00

36.00

39.00

12.00

19.00

 

IG

971.00 (842.00–1495.00)

0.00

321.50 (300.00–343.00)

407.50 (362.00–453.00)

55.00

456.5 (412.00–501.00)

450.00 (407.00–493.00)

23.00

30.00

6.00

50.00

59.00

  1. Overview over the quantitative analysis. Our findings indicate a tendency towards a loss of Satb2+ neurons in layer 5 and an increase of Tbr1+ cells throughout all cortical layers
  2. SG supragranular, IG infragranular, FCD focal cortical dysplasia, PLx perilesional cortex