Fig. 5
Sex differences in pY1472-GluN2B phosphorylation, Fyn, and PLCγ in PSD enrichments of the frontal cortex. a, e, i Main effects of sex on the pY1472-GluN2B:total GluN2B ratio, abundance of Fyn, and abundance of PLCγ in PSD and cSM enrichments of the frontal cortex. b, f, j Developmental trajectories of pY1472-GluN2B:total GluN2B ratio, Fyn, and PLCγ in females and males in the PSD of the frontal cortex. c, g, k Main effects of sex the pY1472-GluN2B:total GluN2B ratio, abundance of Fyn, and abundance of PLCγ in PSD enrichments of the hippocampus. d, h, l Developmental trajectories of the pY1472-GluN2B:total GluN2B ratio, Fyn, and PLCγ in females and males in the PSD of the hippocampus. m Negative correlation of levels of Fyn with pY1472-GluN2B:total GluN2B ratio in PSD enrichments of the frontal cortex across all age groups. n Positive correlation of levels of Fyn with pY1472-GluN2B:total GluN2B ratio in PSD enrichments of the frontal cortex at P28 only. o Negative correlation of levels of Fyn with pY1472-GluN2B:total GluN2B ratio in PSD enrichments of the hippocampus across all age groups. p Correlation of levels of Fyn with pY1472-GluN2B:total GluN2B ratio in PSD enrichments of the hippocampus at P28 only (dotted line indicates positive correlation when two outlying data points are excluded). PSD postsynaptic density, cSM crude synaptic membrane, FCx frontal cortex, N.S. not significant. *p ≤ 0.055; **p ≤ 0.007. Error bars represent SEM