Fig. 6

Effects of DTNBP1 genotype on the GluN2B-GluN2A switch in the frontal cortex and hippocampus. a, e, i Main effects of DTNBP1 genotype [wild-type (+/+), heterozygous DTNBP1 mutant (+/−), and homozygous DTNBP1 null mutant (−/−)] on GluN2B:GluN2A, GluN2B:GluN1, and GluN2A:GluN1 ratios in PSD enrichments of the frontal cortex. b, f, j Developmental trajectories of GluN2B:GluN2A, GluN2B:GluN1, and GluN2A:GluN1 ratios in wild-type (+/+), heterozygous DTNBP1 mutant (+/−), and homozygous DTNBP1 null mutant (−/−) mice in the PSD of the frontal cortex. c, g, k Main effects of DTNBP1 genotype [wild-type (+/+) and homozygous DTNBP1 null mutant (−/−)] on GluN2B:GluN2A, GluN2B:GluN1, and GluN2A:GluN1 ratios in PSD enrichments of the hippocampus. d, h, l Developmental trajectories of GluN2B:GluN2A, GluN2B:GluN1, and GluN2A:GluN1 ratios in wild-type (+/+) and homozygous DTNBP1 null mutant (−/−) mice in the PSD of the hippocampus. Images of representative blots for all hippocampal proteins are provided in Additional file 1: Figure S3. For bar graphs in panels a, c, e, g, i, and k, data are collapsed across age groups. Refer to Table 2 for sample sizes. PSD postsynaptic density, cSM crude synaptic membrane, FCx frontal cortex, N.S. not significant. *p < 0.05. Error bars represent SEM