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Fig. 8 | Journal of Neurodevelopmental Disorders

Fig. 8

From: Effects of sex and DTNBP1 (dysbindin) null gene mutation on the developmental GluN2B-GluN2A switch in the mouse cortex and hippocampus

Fig. 8

DTNBP1 genotype differences in pY1472-GluN2B phosphorylation, Fyn, and PLCγ in PSD enrichments of the frontal cortex and hippocampus. a, e, i, m Main effects of DTNBP1 genotype on the pY1472-GluN2B:total GluN2B ratio, abundance of Fyn, pY527-Src phosphorylation, and abundance of PLCγ in PSD enrichments of the frontal cortex. b, f, j, n Developmental trajectories of pY1472-GluN2B:total GluN2B ratio, abundance of Fyn, pY527-Src phosphorylation, and abundance of PLCγ in mice of different DTNBP1 genotypes in the PSD of the frontal cortex. c, g, k, o Main effects of DTNBP1 genotype on the pY1472-GluN2B:total GluN2B ratio, abundance of Fyn, pY527-Src phosphorylation, and abundance of PLCγ in PSD enrichments of the hippocampus. d, h, l, p Developmental trajectories of pY1472-GluN2B:total GluN2B ratio, abundance of Fyn, pY527-Src phosphorylation, and abundance of PLCγ in mice of different DTNBP1 genotypes in the PSD of the hippocampus. *p < 0.05; ***p ≤ 0.0005. N.S. not significant. Error bars represent SEM

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