Fig. 1

General abnormalities of Mecp2 ^−/Y rats. a Body weight of Mecp2 ^−/Y rats was significantly lower than that of WT littermates at P4w, and the difference became larger with growth (***P < 0.001, **P < 0.01; Student’s t test). Mecp2 ^−/Y rats also showed growth retardation (b), prolapsed penis (c), and malocclusion (d). e Typical hindlimb grasping seen in Mecp2 ^−/Y mice was not observed in Mecp2 ^−/Y rats