Fig. 2

Reduced muscle strength and locomotor activity. a Mecp2 ^−/Y rats exhibited decreased forelimb grip strength compared to WT (***P < 0.001, **P < 0.01, *P < 0.05; Student’s t test). b In comparison to the WT, both Mecp2 ^−/Y rats and mice showed a significant decrease in grip strength (Student’s t test). c No statistical significance in the grip strength differences was found between species after normalization to the WT levels. d, e Locomotor activity was also significantly reduced in Mecp2 ^−/Y rodents. No statistical significance was found between species either, although the null rats appeared to move less (Student’s t test)