Fig. 3

Social behavior defects of Mecp2 ^−/Y rats. a, b The habituation time in side chambers had no significant difference in Mecp2 ^−/Y animals and WT littermates. c, d The time spending of both Mecp2 ^−/Y animals in the intruder chamber (Animal 1) was more than in the empty bucket chamber (Empty). e, f The animal preference disappeared in both Mecp2 ^−/Y animals. Familiar animal is indicated as Animal 1, and unfamiliar animal is labeled as Animal 2. (***P < 0.001, **P < 0.01, * P < 0.05; Student’s t test)