Table 2 Characteristics of NF1 males versus NF1 females on ADI-R subscales, Conners, SRS and verbal IQ

Mean (SD)

ADI-R: reciprocal social interaction (A)

Failure to use non-verbal behaviours to regulate social interaction (A1)

3.61 (1.74)

1.74 (1.45)

4.98

<0.001

Failure to develop peer relationships (A2)

5.19 (2.53)

3.57 (2.56)

3.08

0.003

Lack of shared enjoyment (A3)

3.30 (1.75)

1.71 (1.67)

4.47

<0.001

Lack of socio-emotional reciprocity (A4)

4.63 (2.26)

2.76 (2.09)

4.15

<0.001

ADI-R: communication (B)

Lack/delay in spoken language and failure to compensate through gestures (B1)

2.85 (2.56)

1.57 (2.11)

2.62

0.01

Lack of varied make-believe play (B4)

3.96 (2.06)

2.06 (2.28)

2.92

0.004

Relative failure to initiate/sustain conversational interchange (B2)

2.83 (1.40)

1.45 (1.23)

5.05

<0.001

Stereotyped, repetitive or idiosyncratic speech (B3)

3.33 (1.49)

2.10 (1.96)

3.51

0.001

ADI-R: restricted, repetitive and stereotyped patterns of behaviour (C)

Encompassing preoccupation or circumscribed pattern of interest (C1)

1.57 (1.34)

0.66 (0.96)

3.70

<0.001

Apparently compulsive adherence to non-functional routines or rituals (C2)

1.44 (1.29)

1.19 (1.42)

0.91

0.364

Stereotyped and repetitive motor mannerisms (C3)

0.57 (0.82)

0.52 (0.80)

0.30

0.764

Preoccupation with parts of objects or non-functional elements of material (C4)

1.20 (0.88)

0.74 (0.73)

2.77

0.007

ADOS-SA total

8.11 (4.42)

4.52 (4.03)

4.10

<0.001

ADOS-RRB total

1.41 (1.54)

0.69 (1.33)

2.40

0.018

ADOS overall total (SA + RRB)

9.48 (5.28)

5.50 (4.46)

3.92

<0.001

Conners-inattention^a

67.97 (13.64)

68.03 (14.41)

−0.02

0.981

Conners-hyperactivity^a

67.19 (15.53)

66.82 (16.64)

0.14

0.890

SRS T scores

72.17 (16.09)

67.00 (15.81)

2.25

0.025

Verbal IQ

89.98 (14.19)

95.38 (16.36)

−1.67

0.099