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Fig. 3 | Journal of Neurodevelopmental Disorders

Fig. 3

From: Effects of early-life exposure to THIP on phenotype development in a mouse model of Rett syndrome

Fig. 3

THIP administration improved motor function of MECP2-null mice. a Significant main effects of THIP treatment (F = 23.74, df = 1, P < 0.001) and genotype (F = 147.85, df = 1, P < 0.001) were observed, as well as a significant interaction (F = 12.04, df = 1, P < 0.001). (### P < 0.001, two-way ANOVA). The grip strength of MECP2-null mice was significantly increased with THIP treatment (WT: n = 18 and n = 18 mice; MECP2-null: n = 23 and n = 22; vehicle and THIP, respectively; ***P < 0.001, Tukey’s post hoc). b Significant main effects of THIP treatment (F = 5.26, df = 1, P < 0.05) and genotype (F = 30.4, df = 1, P < 0.001) were observed, as well as a significant interaction (F = 13.25, df = 1, P < 0.001) (# P < 0.05, two-way ANOVA). THIP administration significantly reduced the footfault ratio (including both hindlimb and forelimb) of MECP2-null mice (WT: n = 22 and n = 23 mice; MECP2-null: n = 20 and n = 25; vehicle and THIP, respectively; ***P < 0.001, Tukey’s post hoc). c The spontaneous locomotion of WT and MECP2-null mice was not significantly affected by THIP treatment. The main effect of THIP treatment was not significant (F = 0.26, df = 1, P = 0.614), as the main effect of genotype (F = 3.00, df = 1, P = 0.095). The interaction of these two factors was not significant (F = 0.99, df = 1, P = 0.329) (WT: n = 8 and n = 7 mice; MECP2-null: n = 9 and n = 6; vehicle and THIP, respectively; two-way ANOVA)

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