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Fig. 1 | Journal of Neurodevelopmental Disorders

Fig. 1

From: Acamprosate in a mouse model of fragile X syndrome: modulation of spontaneous cortical activity, ERK1/2 activation, locomotor behavior, and anxiety

Fig. 1

UP state recordings. Spontaneous UP states were measured in slices from P18–25 mice for 5 min in layer IV of the somatosensory cortex. Duration (a), amplitude (b), and number of events (c) were analyzed by two-way ANOVA with pairwise comparisons corrected using FDR method (two-tailed). Representative traces are shown in panel (d). There was a significant increase in UP state duration in the KO + VEH-treated mice compared to the WT + VEH-treated mice indicating a baseline effect of genotype. Bath application of 200 μM acamprosate significantly decreased the elevated UP state duration in the KO mice indicating a significant treatment although the acamprosate-treated KO slices still had UP state durations that were longer than WT + VEH slices. There was a trend towards a decreased UP state duration in the WT + Acamp group compared to the WT + VEH group. For number of events, there was a main effect of gene, and the KO + VEH slices had more UP state events than the WT + Acamp-treated mice. No change in amplitude was observed. WT + VEH, n = 16; WT + Acamp, n = 14; KO + VEH, n = 27; KO + Acamp, n = 25 slices; data shown are LS mean ± SEM; *p < 0.05, †p < 0.1; N.S. = not significant

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