Combined genome-wide linkage and targeted association analysis of head circumference in autism spectrum disorder families

Table 2 Lead SNP associations on chromosome 6

SNP	MAF	REF/ALT	Position (hg19)	Stratification^a	p value
Complete sample
rs849886	0.41	A/G	22,291,367	0.77	1.30E−04
rs9379751	0.39	A/G	25,292,214	0.31	1.09E−04
rs2690129	0.46	G/T	25,297,658	0.35	6.90E−05
rs9295654	0.3	A/G	25,312,755	0.61	4.30E−05
rs9467466	0.3	C/T	25,312,915	0.55	7.78E−05
Family 1
rs17586672	0.17	C/T	23,941,746	0.79	1.72E−07
rs1277145	0.24	A/G	24,060,381	0.25	5.38E−07
rs529648	0.27	A/G	24,939,867	0.25	5.38E−07
rs6900224	0.16	C/T	25,437,986	0.6	3.65E−06
rs12211633	0.46	C/T	34,050,917	0.11	2.41E−06

SNPs ordered by position
^aStratification is calculated by calculating the likelihood ratio for a model where between and within family genotype metrics are both estimated, compared with a model where both metrics are held equal. The stratification value given in the table is a p value in connection with this likelihood ratio test (<0.05 indicating significant likelihood of stratification)

ISSN: 1866-1955