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Table 4 Outcome measures of autistic and non-autistic repetitive behaviors in fragile X syndrome

From: Updated report on tools to measure outcomes of clinical trials in fragile X syndrome

Domain Outcome measure Shorter term Longer term Quality of tools
Autistic behavior
  ADOS Yes Yes + [147155]
SRS Yes   +/++ [15, 46, 7881, 112, 113]
CARS Yes   + [160166]
SCQ Yes   + [162, 167, 173, 174]
RBS-R Yes   + [15, 179184]
Repetitive non-autistic behavior
  RBS-R Yes   + [15, 66, 179, 180, 184, 191, 192, 194]
RBQ Yes   + [189]
BPI-S Yes   + [179, 195, 196]
  1. Abbreviations: ADI-R Autism Diagnostic Interview-Revised, ADOS Autism Diagnostic Schedule, SRS Social Responsiveness Scale, CARS Children Autism Rating Scale, SCQ Social Communication Questionnaire, RBS-R Repetitive Behavior Scale Revised, RBQ Repetitive Behavior Questionnaire, BPI-S Behavior Problems Inventory, Short Form, Shorter term deemed suitable for clinical trials lasting <12 months, Longer-term deemed suitable for clinical trials lasting >=12 months, Grading system: +++ strong evidence, ++ moderate evidence, + limited evidence, ? unknown due to poor methodological quality, blank cell no evidence available