Updated report on tools to measure outcomes of clinical trials in fragile X syndrome

Table 4 Outcome measures of autistic and non-autistic repetitive behaviors in fragile X syndrome

Domain	Outcome measure	Shorter term	Longer term	Quality of tools
Autistic behavior
	ADOS	Yes	Yes	+ [147–155]
	SRS	Yes		+/++ [15, 46, 78–81, 112, 113]
	CARS	Yes		+ [160–166]
	SCQ	Yes		+ [162, 167, 173, 174]
	RBS-R	Yes		+ [15, 179–184]
Repetitive non-autistic behavior
	RBS-R	Yes		+ [15, 66, 179, 180, 184, 191, 192, 194]
	RBQ	Yes		+ [189]
	BPI-S	Yes		+ [179, 195, 196]

Abbreviations: ADI-R Autism Diagnostic Interview-Revised, ADOS Autism Diagnostic Schedule, SRS Social Responsiveness Scale, CARS Children Autism Rating Scale, SCQ Social Communication Questionnaire, RBS-R Repetitive Behavior Scale Revised, RBQ Repetitive Behavior Questionnaire, BPI-S Behavior Problems Inventory, Short Form, Shorter term deemed suitable for clinical trials lasting <12 months, Longer-term deemed suitable for clinical trials lasting >=12 months, Grading system: +++ strong evidence, ++ moderate evidence, + limited evidence, ? unknown due to poor methodological quality, blank cell no evidence available

ISSN: 1866-1955