Fig. 4

Delta rhythmicity is increased in children with Angelman syndrome relative to neurotypical controls during sleep. Black: neurotypical (NT), red: AS. a Occipital power spectra comparing wakefulness and sleep in neurotypical and AS children. Wake data are re-plotted from Fig. 3d; sleep data are re-plotted in d. Representative sleep EEGs from b a neurotypical child and c a child with Angelman syndrome illustrate delta oscillations in AS. d, e Occipital power spectra during sleep (NT: n = 54, AS: n = 13; shading indicates ±sem) show an increase in delta power in AS. f Group analyses reveal increased delta power generalizes across the neocortex (***p < 0.0001, Student’s t tests). g Delta dynamics (IQR) are also increased in all regions (***p < 0.0001)