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Table 1 Characteristics of study subjects

From: Delta rhythmicity is a reliable EEG biomarker in Angelman syndrome: a parallel mouse and human analysis

  Neurotypical Angelman
Total patients 72 28
 Age (years) 7.0 ± 0.2 5.8 ± 0.3
 Male 42 (58%) 14 (50%)
 Female 30 (42%) 14 (50%)
 Molecular diagnosis N/A Class 1 deletion: 7
Class 2 deletion: 10
UBE3A mutation: 6
Atypical deletion: 2
Uniparental disomy: 1
Imprinting defect: 1
Abnormal DNA methylation, negative for deletion: 1
 History of seizures 0 (0%) 26 (93%)
Patients with wake in EEG 54 (75%) 26 (93%)
 Age (years) 6.6 ± 0.3 5.8 ± 0.3
 Male 30 (56%) 14 (54%)
 Female 24 (44%) 12 (46%)
 Wakeful EEG length (min) 7.9 ± 1.0 18.2 ± 2.3
 Seizures under control at time of first recording or no seizure history 54 (100%) 24 (92%)
Patients with sleep in EEG 54 (75%) 13 (46%)
 Age (years) 7.1 ± 0.3 6.0 ± 0.4
 Male 32 (59%) 8 (62%)
 Female 22 (41%) 5 (38%)
 Sleep EEG length (min) 13.6 ± 0.8 22.0 ± 2.4
 Seizures under control at time of first recording or no seizure history 54 (100%) 12 (92%)