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Table 3 Logistic regression analysis of the associations between breathing irregularities, age and mutation type

From: Autonomic breathing abnormalities in Rett syndrome: caregiver perspectives in an international database study

 

Breath-holding (n = 378)

Hyperventilation (n = 386)

Abdominal bloating (n = 408)

 

Crude OR (95% CI)

p

Adjusted OR (95% CI)

p

Crude OR (95% CI)

p

Adjusted OR (95% CI)

p

Crude OR (95% CI)

p

Adjusted OR (95% CI)

p

Age group

 0–6

REF

 

REF

 

REF

 

REF

 

REF

 

REF

 

 7–12

1.70 (0.83, 3.46)

0.15

1.53 (0.73, 3.20)

0.26

0.54 (0.28, 1.07)

0.08

0.49 (0.25, 0.99)

0.05

0.90 (0.46, 1.74)

0.75

0.88 (0.45, 1.75)

0.72

 13–19

1.09 (0.54, 2.21)

0.81

1.02 (0.49, 2.11)

0.96

0.48 (0.24, 0.95)

0.04

0.45 (0.22, 0.92)

0.03

1.05 (0.54, 2.06)

0.88

1.08 (0.54, 2.14)

0.83

 20+

0.85 (0.41, 1.77)

0.67

0.80 (0.38, 1.69)

0.56

0.55 (0.27, 1.12)

0.10

0.54 (0.26, 1.10)

0.09

1.77 (0.90, 3.50)

0.10

1.79 (0.90, 3.58)

0.10

Mutation type

 C-terminal deletion

REF

 

REF

 

REF

 

REF

 

REF

 

REF

 

 Early truncating

2.14 (0.66, 6.88)

0.20

2.21 (0.68, 7.16)

0.19

1.37 (0.52, 3.62)

0.53

1.38 (0.52, 3.69)

0.52

1.75 (0.67, 4.58)

0.25

1.78 (0.67, 4.71)

0.24

 Large deletion

1.95 (0.60, 6.32)

0.27

1.80 (0.55, 5.89)

0.33

1.26 (0.47, 3.38)

0.65

1.27 (0.47, 3.43)

0.64

1.31 (0.50, 3.46)

0.58

1.47 (0.55, 3.92)

0.44

 p.Arg106Trp

0.93 (0.26, 3.27)

0.91

1.05 (0.29, 3.72)

0.95

1.29 (0.39, 4.22)

0.68

1.28 (0.39, 4.23)

0.69

1.17 (0.35, 3.88)

0.80

1.04 (0.31, 3.53)

0.94

 p.Arg133Cys

0.88 (0.32, 2.42)

0.81

0.84 (0.30, 2.32)

0.73

1.47 (0.57, 3.78)

0.42

1.52 (0.59, 3.92)

0.39

1.17 (0.45, 3.03)

0.75

1.22 (0.47, 3.20)

0.69

 p.Arg168*

0.86 (0.34, 2.17)

0.75

0.91 (0.36, 2.33)

0.85

1.16 (0.49, 2.75)

0.73

1.04 (0.43, 2.49)

0.93

1.75 (0.75, 4.10)

0.20

1.67 (0.70, 3.97)

0.25

 p.Arg255*

1.24 (0.49, 3.15)

0.65

1.27 (0.50, 3.27)

0.62

1.47 (0.63, 3.45)

0.38

1.41 (0.60, 3.34)

0.43

1.13 (0.48, 2.64)

0.79

1.13 (0.48, 2.67)

0.79

 p.Arg270*

1.13 (0.38, 3.38)

0.83

1.22 (0.40, 3.73)

0.72

1.24 (0.45, 3.42)

0.67

1.14 (0.41, 3.17)

0.80

1.17 (0.43, 3.20)

0.77

1.09 (0.39, 3.03)

0.87

 p.Arg294*

0.93 (0.33, 2.62)

0.89

0.96 (0.34, 2.73)

0.94

1.18 (0.44, 3.12)

0.75

1.18 (0.44, 3.15)

0.74

0.92 (0.35, 2.46)

0.87

0.88 (0.33, 2.39)

0.81

 p.Arg306Cys

1.04 (0.36, 3.02)

0.94

0.99 (0.34, 2.89)

0.99

2.01 (0.74, 5.41)

0.17

1.91 (0.70, 5.20)

0.21

1.20 (0.45, 3.22)

0.71

1.30 (0.48, 3.51)

0.60

 p.Thr158Met

1.11 (0.41, 2.99)

0.83

1.13 (0.42, 3.05)

0.82

1.47 (0.60, 3.61)

0.40

1.43 (0.58, 3.52)

0.44

2.01 (0.85, 4.75)

0.11

1.97 (0.83, 4.69)

0.13

 Other mutations

0.56 (0.23, 1.35)

0.20

0.60 (0.25, 1.48)

0.27

0.94 (0.40, 2.22)

0.90

0.85 (0.36, 2.04)

0.72

1.11 (0.48, 2.57)

0.81

1.07 (0.46, 2.52)

0.87

  1. OR was adjusted for age group and mutation type
  2. OR odds ratio, CI confidence interval, REF reference category
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Journal of Neurodevelopmental Disorders

ISSN: 1866-1955

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