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Table 4 SCQ and ADOS-2 performances in relation to best-estimate ASD diagnoses

From: Diagnoses and characteristics of autism spectrum disorders in children with Prader-Willi syndrome

  SCQ performance in relation to ASD diagnoses ADOS-2 performance in relation to ASD diagnoses
% 95% CI % 95% CI
Sensitivity 77.78 (28.36–93.49) 100.00 (78.12–1.00)
Specificity 73.44 (64.91–80.85) 89.06 (82.00–93.67)
PPV 29.17 (16.95–46.06) 56.25 (37.88–73.16)
Adjusted PPV 48.71 (33.41–64.21) 75.75 (59.11–88.06)
NPV 95.92 (88.88–98.88) 100.00 (95.93–1.00)
  1. Adjusted PPV’s used a higher estimation of ASD in PWS (~25%) based on previous literature and the formula [adjusted PPV = sensitivity × prevalence/sensitivity × prevalence + (1−specificity) × (1−prevalence)]
  2. CI confidence interval, PPV positive predictive value, NPV negative predictive value