Fig. 5
Female mice do not exhibit the effect of DAT Val559 on photopic ERG responses. a Photopic ERG b-wave amplitudes (μV) of female mice plotted as a function of light adaption time (minutes; HOM: open circles; HET: filled circles; and WT: filled triangles). The HOM group does not differ from HET or WT (F (2,128) = 0.869, P = 0.422, two-way ANOVA, n = 3–9 mice). b Female HET (left column, open circles, F (1,152) = 64.43, ***P < 0.001, two-way ANOVA, n = 9–12 mice) and WT (right column, open circles, F (1,120) = 18.89, ***P < 0.001, two-way ANOVA, n = 3–14 mice) show elevated photopic amplitudes compared to the male cohort (filled circles), while amplitudes in HOM remained the same independent of sex (middle column, F (1,112) = 3.860, P = 0.0519, two-way ANOVA, n = 7–9 mice). c Averaged increases were quantified by genotype and sex (from left to right, HET: **P = 0.0070, Mann-Whitney test; HOM: P = 0.052, Mann-Whitney test; WT: **P = 0.0038, t-test). All data are represented as means ± SEM