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Table 5 Percentage of individuals that scored as “impaired” on SCQ non-verbal algorithm items

From: Prospective study of autism phenomenology and the behavioural phenotype of Phelan–McDermid syndrome: comparison to fragile X syndrome, Down syndrome and idiopathic autism spectrum disorder

  

% impairment

Chi-square

  

Domain

Item

PMS

FraX

DS

ASD

df

χ2

p valuea

Post hoc < .01

Communication

Imitation

76.7

46.7

33.3

83.3

3

15.53

.001

ASD > FraX, DS; PMS > DS

+b

Pointing

86.7

56.7

33.3

70.0

3

15.87

.001

PMS > DS

+

Gestures

70.0

46.7

36.7

60.0

3

5.53

.137

N/A

N/A

Nodding to mean yes

86.7

46.7

23.3

83.3

3

31.50

< .001

ASD, PMS > FraX, DS

+ +

Head shaking to mean no

73.3

36.7

23.3

76.7

3

21.22

< .001

ASD > FraX, DS; PMS > DS

+

Imitative social play

80.0

60.0

16.7

76.7

3

28.22

< .001

ASD, PMS, FraX > DS

+

Imaginative play

83.3

80.0

36.7

80.0

3

21.05

< .001

ASD, PMS, FraX > DS

+

Repetitive Behaviour

Rituals

40.0

73.3

46.7

83.3

3

17.18

.001

ASD > PMS, DS; FraX > PMS

− −c

Unusual preoccupations

60.0

63.3

20.0

70.0

3

19.44

< .001

ASD, PMS, FraX > DS

+

Stereotyped play

66.7

60.0

30.0

76.7

3

13.97

.003

ASD, PMS > DS

+

Circumscribed interests

30.0

56.7

36.7

60.0

3

7.40

.060

N/A

N/A

Sensory interests

53.3

43.3

13.3

83.3

3

29.15

< .001

ASD > FRaX, DS; PMS > DS

+

Hand stereotypies

70.0

86.7

33.3

90.0

3

27.40

< .001

ASD, PMS, FRaX > DS

+

Body stereotypies

56.7

60.0

23.3

66.7

3

12.64

.005

ASD, FraX > DS

N/A

Reciprocal Social Interaction

Inappropriate facial expressions

40.0

23.3

6.7

40.0

3

11.49

.009

ASD, PMS > DS

+

Use of other’s body to communicate

83.3

56.7

40.0

86.7

3

20.10

< .001

ASD, PMS > DS

+

Friends

70.0

80.0

30.0

76.7

3

19.72

< .001

ASD, PMS, FRaX > DS

+

Eye contact

56.7

53.3

23.3

56.7

3

8.57

.036

N/A

N/A

Social smiling

40.0

36.7

16.7

66.7

3

13.66

.003

ASD > DS

N/A

Showing and directing attention

70.0

46.7

16.7

36.7

3

15.69

.001

PMS > ASD, DS

+ +

Offering to share

80.0

63.3

33.3

76.7

3

15.41

.001

ASD, PMS > DS

+

Seeking to share enjoyment

43.3

26.7

23.3

36.7

3

2.27

.519

N/A

N/A

Offering comfort

83.3

56.7

20.0

86.7

3

32.27

< .001

ASD, PMS, FraX > DS

+

Quality of social overtures

56.7

26.7

13.3

46.7

3

12.67

.005

ASD, PMS > DS

+

Range of facial expression

63.3

56.7

23.3

80.0

3

17.82

< .001

ASD, PMS, FRaX > DS

+

Interest in children

60.0

56.7

26.7

90.0

3

21.91

< .001

ASD > PMS, DS

Response to other children’s approaches

53.3

63.3

23.3

86.7

3

23.64

< .001

ASD > PMS, DS; FraX > DS

Imaginative play with peers

90.0

86.7

60.0

100.0

3

14.12 d

.001

ASD > DS

N/A

Group play

86.7

73.3

46.7

86.7

3

12.64

.005

ASD, PMS > DS

+

  1. aSignificant differences are highlighted in italics (p < .01)
  2. b“+” indicates that significantly more individuals in the PMS group scored as impaired one of the comparison groups
  3. c“−” indicates significantly fewer individuals in the PMS group scored as impaired than one of the comparison groups
  4. dFisher’s exact test calculated