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Table 1 Demographic and clinical characteristics of patients with Lennox-Gastaut syndrome

From: Few individuals with Lennox-Gastaut syndrome have autism spectrum disorder: a comparison with Dravet syndrome

  LGS (N = 50) Cryptogenic LGS (N = 28) Symptomatic LGS (N = 22) p
Gender (male/female) 38/12 21/7 17/5 0.852
Age at conclusion of study (years) 12.9 ± 6.5 12.5 ± 6.1 13.5 ± 7.1 0.875
Age at evaluation (years) 9.3 ± 6.2 9.9 ± 5.6 8.4 ± 7.0 0.418
Age at seizure onset (months) 35.3 ± 29.6 49.4 ± 29.5 17.4 ± 18.1 0.007*
Seizure type
 Tonic 48 (96%) 26 (92.9%) 22 (100.0%) 0.309
 GTCS/secondary GTCS 34 (68%) 18 (64.3%) 16 (72.7%) 0.525
 Complex/simple partial 20 (40%) 11 (39.3%) 9 (40.9%) 0.907
 Atypical absence 20 (40%) 12 (42.9%) 8 (36.4%) 0.642
 Myoclonic 16 (32%) 8 (28.6%) 8 (36.4%) 0.558
 Spasms 12 (24%) 1 (3.6%) 11 (50.0%) 0.001*
 Drops 11 (22%) 5 (17.9%) 6 (27.3%) 0.650
 Atonic 8 (16%) 5 (17.9%) 3 (13.6%) 0.988
Status epilepticus 6 (12%) 3 (10.7%) 3 (13.6%) 1.000
EEG characteristics
 Slow background activity 34 (68%) 18 (64.3%) 16 (72.7%) 0.525
 Generalized polyspikes 49 (98%) 28 (100.0%) 21 (95.5%) 0.440
 Diffuse SSW pattern 36 (72%) 22 (78.6%) 14 (63.6%) 0.243
 Focal discharges 43 (86%) 24 (85.7%) 19 (86.4%) 1.000
 Burst-suppression pattern 11 (22%) 6 (21.4%) 5 (22.7%) 1.000
Antiepileptic drugs
 2 13 (26%) 10 (35.7%) 3 (13.6%) 0.768
 ≥ 3 37 (74%) 18 (64.3%) 19 (86.4%)  
Seizure free 14 (28%) 13 (46.4%) 1 (4.5%) 0.001*
  1. GTCS generalized tonic-clonic seizure, SSW slow spike-wave
  2. * p < 0.05 (two-sided) was statistically significant