Table 1 Demographic and clinical characteristics of patients with Lennox-Gastaut syndrome
|  | LGS (N = 50) | Cryptogenic LGS (N = 28) | Symptomatic LGS (N = 22) | p |
|---|---|---|---|---|
Gender (male/female) | 38/12 | 21/7 | 17/5 | 0.852 |
Age at conclusion of study (years) | 12.9 ± 6.5 | 12.5 ± 6.1 | 13.5 ± 7.1 | 0.875 |
Age at evaluation (years) | 9.3 ± 6.2 | 9.9 ± 5.6 | 8.4 ± 7.0 | 0.418 |
Age at seizure onset (months) | 35.3 ± 29.6 | 49.4 ± 29.5 | 17.4 ± 18.1 | 0.007* |
Seizure type | ||||
 Tonic | 48 (96%) | 26 (92.9%) | 22 (100.0%) | 0.309 |
 GTCS/secondary GTCS | 34 (68%) | 18 (64.3%) | 16 (72.7%) | 0.525 |
 Complex/simple partial | 20 (40%) | 11 (39.3%) | 9 (40.9%) | 0.907 |
 Atypical absence | 20 (40%) | 12 (42.9%) | 8 (36.4%) | 0.642 |
 Myoclonic | 16 (32%) | 8 (28.6%) | 8 (36.4%) | 0.558 |
 Spasms | 12 (24%) | 1 (3.6%) | 11 (50.0%) | 0.001* |
 Drops | 11 (22%) | 5 (17.9%) | 6 (27.3%) | 0.650 |
 Atonic | 8 (16%) | 5 (17.9%) | 3 (13.6%) | 0.988 |
Status epilepticus | 6 (12%) | 3 (10.7%) | 3 (13.6%) | 1.000 |
EEG characteristics | ||||
 Slow background activity | 34 (68%) | 18 (64.3%) | 16 (72.7%) | 0.525 |
 Generalized polyspikes | 49 (98%) | 28 (100.0%) | 21 (95.5%) | 0.440 |
 Diffuse SSW pattern | 36 (72%) | 22 (78.6%) | 14 (63.6%) | 0.243 |
 Focal discharges | 43 (86%) | 24 (85.7%) | 19 (86.4%) | 1.000 |
 Burst-suppression pattern | 11 (22%) | 6 (21.4%) | 5 (22.7%) | 1.000 |
Antiepileptic drugs | ||||
 2 | 13 (26%) | 10 (35.7%) | 3 (13.6%) | 0.768 |
 ≥ 3 | 37 (74%) | 18 (64.3%) | 19 (86.4%) |  |
Seizure free | 14 (28%) | 13 (46.4%) | 1 (4.5%) | 0.001* |