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Table 2 Comparison of clinical features among LGS patients with and without intellectual disability

From: Few individuals with Lennox-Gastaut syndrome have autism spectrum disorder: a comparison with Dravet syndrome

  Without ID (N = 7) With ID (N = 43) p
Gender (male) 5 (71.4%) 33 (76.7%) 1.000
Age at seizure onset (month) 50.6 ± 35.6 26.2 ± 20.0 0.009*
Age at evaluation (years) 11.9 ± 8.6 8.9 ± 5.8 0.400
History of infantile spasms 0 (0.0%) 8 (18.6%) 0.580
Seizure types
 Tonic 6 (85.7%) 42 (97.7%) 0.263
 GTCS/secondary GTCS 5 (71.4%) 29 (67.4%) 1.000
 Complex partial seizure 2 (28.6%) 18 (41.9%) 0.687
 Atypical absence 4 (57.1%) 16 (37.2%) 0.416
 Myoclonic 2 (28.6%) 14 (32.6%) 1.000
 Spasms 0 (0.0%) 12 (27.9%) 0.174
 Drops 1 (14.3%) 10 (23.3%) 1.000
 Atonic 1 (14.3%) 7 (16.3%) 1.000
Status epilepticus 1 (14.3%) 5 (11.6%) 1.000
EEG characteristics
 Slow background activity 4 (57.1%) 30 (69.8%) 0.666
 Generalized polyspikes 7 (100.0%) 42 (97.7%) 1.000
 Diffuse SSW pattern 6 (85.7%) 30 (69.8%) 0.657
 Focal discharges 5 (71.4%) 38 (88.4%) 0.250
 Burst-suppression pattern 0 (0.0%) 11 (25.6%) 0.324
Antiepileptic drugs
 2 3 (42.9%) 10 (23.3%) 0.357
 ≥ 3 4 (57.1%) 33 (76.7%)  
Etiology
 Symptomatic 0 (0.0%) 22 (51.2%) 0.014*
 Cryptogenic 7 (100.0%) 21 (48.8%)  
Seizure free 4 (57.1%) 10 (23.3%) 0.085
  1. GTCS generalized tonic-clonic seizure, SSW slow spike-wave
  2. * p < 0.05 (two-sided) was statistically significant