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Table 3 Brain regions showing significant increase in social perception contrasts within and between groups

From: Neural correlates of socio-emotional perception in 22q11.2 deletion syndrome

k t MNI (x,y,z) Hemisphere Region BA
Healthy controls
 Social > Scrambled
 1095 5.36 −40 −39 49 L Inferior parietal lobule 40
  5.26 −47 −34 50 L Postcentral gyrus 2
  4.43 −52 −25 50 L Postcentral gyrus 2
  4.35 −50 −47 56 L Inferior parietal lobule 40
  4.17 −47 − 42 56 L Inferior parietal lobule 40
  4.16 − 41 −47 56 L Inferior parietal lobule 40
  3.69 −53 −22 53 L Postcentral gyrus  
 Nonsocial > Scrambled
 4239 5.92 −13 −103 8 L Cuneus 18
  5.34 −6 −100 14 L Middle occipital gyrus 18
  5.33 −4 −94 23 L Cuneus 19
 1678 6.00 −26 −71 −7 L Lingual gyrus 19
   −22 −73 −14 L Lingual gyrus 18
   −9 −83 −11 L Lingual gyrus 18
 1244 7.86 12 −97 18 R Cuneus 17
  5.65 13 −89 −7 R Lingual gyrus 17
  4.76 16 − 96 −2 R Cuneus 17
 622 6.10 21 −63 13 R Posterior cingulate 31
   17 −62 4 R Posterior cingulate 30
Social > Non-Social No cluster pFWEc < 0.05
22q11DS patients
Social > Scrambled No cluster pFWEc < 0.05
 Nonsocial > Scrambled
 1416 6.45 −13 −91 8 L Cuneus 17
  5.70 −5 − 97 7 L Cuneus 18
  5.68 −11 −96 5 L Cuneus 17
  5.26 −9 −100 12 L Middle occipital gyrus 17
  4.65 −17 − 93 17 L Middle occipital gyrus 18
  4.35 −13 −95 17 L Cuneus 18
 675 5.62 −28 −41 72 L Postcentral gyrus 2
  4.96 −22 −40 73 L Postcentral gyrus 2
  4.53 −26 −39 62 L Postcentral gyrus 3
Social > Non-Social No cluster pFWEc < 0.05
Group comparison
Social > Scrambled No cluster pFWEc < 0.05
Non-social > Scrambled No cluster pFWEc < 0.05
 Social > Non-Social CTRL > VCFS
 1683 5.14 0 46 20 L Medial frontal gyrus 9
  4.93 −11 51 14 L Medial frontal gyrus 10
  4.26 −11 39 18 L Anterior cingulate 32
  4.22 −19 41 15 L Anterior cingulate 32
  4.18 −11 43 19 L Medial frontal gyrus 9
  4.11 −7 46 21 L Medial frontal gyrus 9
  4.09 −13 45 9 L Anterior cingulate 32
  3.92 −5 50 30 L Medial frontal gyrus 9
  3.77 −11 41 11 L Anterior cingulate 32
  3.72 −6 45 11 L Anterior cingulate 32
  3.41 −7 53 28 L Superior frontal gyrus 9
 1466 5.71 52 −61 39 R Inferior parietal lobule 40
  5.05 52 −57 38 R Inferior parietal lobule 40
  4.63 47 −58 35 R Supramarginal gyrus 40
 908 4.80 −26 27 41 L Middle frontal gyrus 8
  4.75 −25 29 45 L Middle frontal gyrus 8
  3.98 −33 25 41 L Middle frontal gyrus 8
  3.97 −16 34 45 L Superior frontal gyrus 8
  3.74 −25 43 34 L Superior frontal gyrus 9
  3.66 −21 37 43 L Superior frontal gyrus 8
  3.53 −25 41 38 L Middle frontal gyrus 9
 659 4.37 42 20 40 R Precuneus 9
  4.23 41 20 44 R Middle frontal gyrus 8
  4.16 34 23 49 R Middle frontal gyrus 6
  3.82 34 2 39 R Middle frontal gyrus 6
  3.79 29 20 37 R Middle frontal gyrus 9
  3.54 36 26 43 R Middle frontal gyrus 8
 551 4.67 13 −43 34 R Posterior cingulate 31
  1. Abbreviations: k cluster size, t t scores, MNI Montreal Neurological Institute, BA Brodman Area