A direct regulatory link between microRNA-137 and SHANK2: implications for neuropsychiatric disorders

Table 1 Experimentally validated miR-137 target genes (summarized in Additional file 1: Table S4) with a significant expression difference in the DLPFC (dorsolateral prefrontal cortex) between SCZ and control individuals. The log₂-fold change and P values were taken from the analysis published by the CommonMind Consortium (summarized in Additional file 1: Table S5). The log₂-fold change was calculated by adding 1 to the respective values. The Benjamini-Hochberg method was used to correct for multiple testing with a false discovery rate of 10%. SCZ schizophrenia, ASD autism spectrum disorders, BD bipolar disorder, ID intellectual disability

Gene symbol	Ensemble ID	Log₂-fold change	P value	Association to neurodevelopmental/neuropsychiatric disease	Ref.
RORA	ENSG00000069667	1.118	1.21E−05	ASD candidate	[43]
CPLX1	ENSG00000168993	0.820	4.60E−04	Wolf Hirschhorn syndrome	[44]
TCF4	ENSG00000196628	1.063	4.97E−04	SCZ, Pitt-Hopkins syndrome	[18, 45]
SIRT1	ENSG00000096717	1.074	5.59E−04	SCZ	[46]
ESRRA	ENSG00000173153	0.888	2.72E−03
CDK6	ENSG00000105810	1.087	3.86E−03	Microcephaly	[47]
XIAP	ENSG00000101966	1.060	4.68E−03	SCZ	[48]
ZNF804A	ENSG00000170396	1.108	5.29E−03	SCZ, BD	[49]
MET	ENSG00000105976	1.132	5.34E−03
CTBP1	ENSG00000159692	0.936	5.77E−03
GRIA1	ENSG00000155511	1.068	8.78E−03	SCZ	[32, 50]
KLF12	ENSG00000118922	1.066	1.10E−02
MSI1	ENSG00000135097	0.865	1.23E−02
KDM5B	ENSG00000117139	1.049	1.45E−02	ID, ASD	[51]
PAQR3	ENSG00000163291	1.067	1.71E−02
TRIM13	ENSG00000204977	1.050	2.28E−02