Table 2 Ingenuity pathway analysis of the 71 previously published experimentally validated miR-137 targets
Category | Diseases and functions | Number of molecules | P value |
|---|---|---|---|
Cell death and survival | Cell death | 48 | 6.43 × 10−16 |
Apoptosis | 46 | 8.91 × 10−19 | |
Necrosis | 41 | 3.42 × 10−14 | |
Neuronal cell death | 17 | 5.74 × 10−9 | |
Cellular movement | Cell movement | 39 | 1.53 × 10−15 |
Migration of cells | 35 | 7.17 × 10−14 | |
Gene expression | Transcription of RNA | 34 | 6.14 × 10−14 |
Expression of RNA | 36 | 2.90 × 10−13 | |
Transcription of DNA | 29 | 4.30 × 10−12 | |
Molecular transport | Transport of molecule | 23 | 4.69 × 10−7 |
Secretion of molecule | 17 | 1.53 × 10−10 | |
Secretion of neurotransmitter | 9 | 5.53 × 10−9 | |
Developmental disorders | Abnormal morphology of embryonic tissue | 17 | 2.36 × 10−10 |
Growth failure | 14 | 3.30 × 10−7 | |
Dysgenesis | 13 | 5.57 × 10−7 | |
Neurological disease | Schizophrenia | 14 | 7.63 × 10−9 |
Cell death of cortical neurons | 9 | 2.38 × 10−8 | |
Congenital malformation of brain | 9 | 6.18 × 10−6 | |
Brain cancer | 8 | 2.38 × 10−6 | |
Apoptosis of cortical neurons | 7 | 2.75 × 10−8 | |
Neurodegeneration of pyramidal neurons | 3 | 3.94 × 10−6 | |
Psychological disorders | Schizophrenia | 14 | 7.63 × 10−9 |
Disorder of basal ganglia | 12 | 2.10 × 10−4 | |
Mood disorders | 9 | 8.92 × 10−5 | |
Major affective disorder | 8 | 1.97 × 10−4 | |
Depressive disorder | 7 | 1.49 × 10−4 | |
Dyssomnia | 4 | 1.43 × 10−4 |