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Table 2 Ingenuity pathway analysis of the 71 previously published experimentally validated miR-137 targets

From: A direct regulatory link between microRNA-137 and SHANK2: implications for neuropsychiatric disorders

Category Diseases and functions Number of molecules P value
Cell death and survival Cell death 48 6.43 × 10−16
Apoptosis 46 8.91 × 10−19
Necrosis 41 3.42 × 10−14
Neuronal cell death 17 5.74 × 10−9
Cellular movement Cell movement 39 1.53 × 10−15
Migration of cells 35 7.17 × 10−14
Gene expression Transcription of RNA 34 6.14 × 10−14
Expression of RNA 36 2.90 × 10−13
Transcription of DNA 29 4.30 × 10−12
Molecular transport Transport of molecule 23 4.69 × 10−7
Secretion of molecule 17 1.53 × 10−10
Secretion of neurotransmitter 9 5.53 × 10−9
Developmental disorders Abnormal morphology of embryonic tissue 17 2.36 × 10−10
Growth failure 14 3.30 × 10−7
Dysgenesis 13 5.57 × 10−7
Neurological disease Schizophrenia 14 7.63 × 10−9
Cell death of cortical neurons 9 2.38 × 10−8
Congenital malformation of brain 9 6.18 × 10−6
Brain cancer 8 2.38 × 10−6
Apoptosis of cortical neurons 7 2.75 × 10−8
Neurodegeneration of pyramidal neurons 3 3.94 × 10−6
Psychological disorders Schizophrenia 14 7.63 × 10−9
Disorder of basal ganglia 12 2.10 × 10−4
Mood disorders 9 8.92 × 10−5
Major affective disorder 8 1.97 × 10−4
Depressive disorder 7 1.49 × 10−4
Dyssomnia 4 1.43 × 10−4