Table 3 Linear trend analyses across difficulty levels for children with ASD
From: Load matters: neural correlates of verbal working memory in children with autism spectrum disorder
| Â | Voxels | MNI coordinates | Z value | p value | Hem. | Region | ||
|---|---|---|---|---|---|---|---|---|
x | y | z | ||||||
Regions where activation increases with difficulty (increasing BOLD signal) | 2170 | − 28 | − 76 | − 6 | 4.25 | 3.64 × 10−6 | L | Middle occipital gyrus |
x | − 24 | − 68 | − 6 | 4.09 |  | L | Lingual gyrus/fusiform gyrus | |
x | − 28 | − 54 | − 6 | 3.91 |  | L | Lingual gyrus | |
x | − 20 | − 86 | 12 | 3.85 |  | L | Cuneus/middle occipital gyrus | |
x | − 22 | − 86 | 22 | 3.82 |  | L | Precuneus | |
1120 | − 2 | − 74 | − 26 | 4.19 | 1.31 × 10−3 | L | Cerebellar vermis | |
x | 28 | − 72 | − 10 | 3.62 |  | R | Fusiform/lingual gyrus | |
x | 0 | − 58 | − 32 | 3.51 |  | L | Culmen/cerebellar vermis | |
x | − 10 | − 64 | − 30 | 3.16 |  | L | Cerebellum | |
960 | 6 | − 28 | − 12 | 4.29 | 3.68 × 10−3 | R | Thalamus | |
x | 6 | − 34 | − 20 | 4.01 |  | R | Culmen | |
x | − 8 | − 24 | − 12 | 3.43 |  | L | Thalamus | |
x | 0 | − 34 | − 46 | 3.42 |  | L | Brain-stem | |
x | − 2 | − 34 | − 30 | 3.41 |  | L | Culmen | |
610 | − 42 | − 4 | 26 | 4.04 | 4.4 × 10−2 | L | Inferior frontal gyrus | |
x | − 58 | 18 | 32 | 3.89 |  | L | Middle frontal gyrus | |
x | − 38 | 22 | 18 | 3.05 |  | L | Insula/inferior frontal gyrus | |
Regions where activation decreases with difficulty (decreasing BOLD signal) | 3908 | 42 | − 68 | 42 | 4.92 | 1.31 × 10−9 | R | Inferior parietal/angular gyrus |
x | 48 | − 58 | 40 | 4.52 |  | R | Inferior parietal lobule | |
x | 48 | − 50 | 36 | 4.49 |  | R | Angular gyrus | |
x | 48 | − 46 | 36 | 4.46 |  | R | Supramarginal gyrus | |
x | 46 | − 44 | 0 | 4.1 |  | R | Middle temporal gyrus | |
3816 | 2 | − 32 | 44 | 4.38 | 1.92 × 10−9 | R | Cingulate gyrus | |
x | − 6 | − 38 | 38 | 4.19 |  | L | Cingulate gyrus | |
x | 6 | − 68 | 36 | 4.02 |  | R | Precuneus | |
x | 12 | − 46 | 30 | 3.79 |  | R | Cingulate gyrus | |
x | − 16 | − 24 | 44 | 3.73 |  | L | Cingulate gyrus | |
1810 | − 64 | − 40 | 30 | 4.37 | 2.38 × 10−5 | L | Inferior parietal lobule | |
x | − 56 | − 56 | 34 | 3.97 |  | L | Angular gyrus | |
843 | − 12 | 62 | 12 | 4.07 | 8.14 × 10−3 | L | Medial frontal gyrus | |
x | − 22 | 66 | 14 | 3.77 |  | L | Middle frontal gyrus | |
x | − 18 | 52 | 8 | 3.58 |  | L | Superior frontal gyrus | |
x | 16 | 58 | 4 | 3.33 | Â | R | Superior frontal gyrus | |
x | − 20 | 42 | 4 | 3.32 |  | L | anterior cingulate | |
604 | 22 | 58 | 18 | 3.44 | 4.6 × 10−2 | R | superior frontal gyrus | |
x | 24 | 52 | 32 | 3.29 | Â | R | middle frontal gyrus | |