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Table 1 Salient ASD, BAP linkage peaks, and CAN and US pedigrees

From: A genome-wide linkage study of autism spectrum disorder and the broad autism phenotype in extended pedigrees

Chr & Band

ASD PPL (%)

BAP PPL (%)

Peak (cM)a

Narrowb

Intermed

Broad

Peak (BP position)c

1p36.22

34

12

26

22–28

16–34

0–34

11,957,977

2q37.2

25

16

250

250

246–250

244–256

236,361,323

6q27

21

2

182

182

180–184

178–188

165,645,201

8q24.22

27

144

148

148–150

148–150

144–150

134,467,348

12p13.31

29

1.5

20

20

18–22

10–28

7,531,425

16p13.2

33

4

24

16–26

10–28

8–28

9,330,226

22q13.1

45

1.5

50

46–62

44–62

42–64

37,698,639

2p13.1

3

22

98

98

96–100

92–104

74,913,089

2q37.3

2

75

264

252–264

248–264

246–264

243,361,159

9p21.3

1.6

67

48

44–62

44–72

42–82

24,428,328

9q31.2

4

28

112

112

110–116

102–118

109,889,954

15q13.3

6

62

22

20–28

14–32

10–32

31,770,967

18q21.1

3

24

72

72

70–72

70–82

45,574,928

Xp22.11

2

21

40

40

40–42

38–46

22,295,443

  1. aBoth ASD and BAP PPLs are shown at the same location, corresponding to the location for the phenotype with the larger PPL (indicated in italics)
  2. bPeak width in cM, defined as the contiguous region around the peak for which the PPL remains ≥ 0.20 (narrow), ≥ 0.10 (intermediate), or ≥ 0.05 (broad), for the phenotype with the larger PPL
  3. cPhysical positions reference Build 37 and are included for convenience only; linkage analysis has a resolution of approximately 1 cM (on average, around 1 M basepairs) at best