Fig. 1

Enlarged receptive field size of visual neurons in the SC of Fmr1^−/y mice. a Schematic of in vivo visual stimulus presentation set up and flashing spot paradigm. b Schematic of the silicon multi-electrode array utilized. c Representative parasagittal section through the SC from a mouse in which recording was performed. The electrode was coated with fluorescent DiI in order to visualize the track and final position within the superficial layers of the SC. d Representative raw traces from recordings in the SC of Fmr1^+/y (black) and Fmr1^−/y (red) mice in response to the stimulus presented in a. e, f Heat maps of the total response to a flashing spot stimulus from representative visual neurons identified in the SC of Fmr1^+/y (e) and Fmr1^−/y (f) mice. g Quantification of the average receptive field (RF) area. *p < 0.05, unpaired t test. h Quantification of the length of the azimuth and elevation axes. *p < 0.05, unpaired t test. i Quantification of the azimuth to elevation axes ratio. j Quantification of the baseline and peak firing rates for individual neurons. ****p ≤ 0.0001, Wilcoxon matched-pairs signed rank test. For g–j, individual values for each identified neuron are shown, and the bar indicates the mean