Fig. 3

Decreased direction selectivity of visual neurons in the SC of Fmr1^−/y mice. a Schematic of drifting square wave visual stimulus paradigm. b Representative raw traces from recordings in the SC of Fmr1^+/y (black) and Fmr1^−/y (red) mice in response to the stimulus presented in a. c, d Quantification of the axis (c) and direction (d) selectivity indices (ASI, DSI) for all neurons identified in response to the drifting square wave stimulus. Individual values for each identified neuron are shown, and the bar indicates the mean. ***p < 0.001, Kolmogorov-Smirnov test. e, f Scatter plots of DSI and ASI for each identified neuron in the SC of Fmr1^+/y (e) and Fmr1^−/y (f) mice. Dotted lines at 0.33 indicate threshold for selectivity. Neurons classified as direction selective (DS) fall in the top right of the plot (light gray shading), while neurons classified as axis selective (AS) fall into the bottom right of the plot (dark gray shading). g, h Relative proportions of each type of neuron identified in the SC of Fmr1^+/y (g) and Fmr1^−/y (h) mice