Fig. 8

Topography of retinogeniculocortical pathway is preserved in Fmr1^−/y mice. a Schematic of tracing paradigm to assess retinogeniculate topography. b, c Coronal sections through the dorsal lateral geniculate nucleus (dLGN, dashed area) reveal the termination zones (TZs) of focally labeled retinal ganglion cells (RGCs) in Fmr1^+/y (b) and Fmr1^−/y (c) mice. d Quantification of the TZ size as a percent of the dLGN. e Schematic of tracing paradigm to assess eye-specific segregation in the dLGN. f, g Coronal sections through the dLGN (dashed area) reveal the terminations of bulk-labeled RGCs projecting from the contralateral (red) and ipsilateral (green) eye of Fmr1^+/y (f) and Fmr1^−/y (g) mice. h Quantification of the amount of overlap between ipsilateral and contralateral inputs in the dLGN, measured as a percent of the ipsilateral patch. i Schematic of tracing paradigm to assess geniculocortical topography. j, k Coronal sections through the dLGN (dashed area) reveal the origination zone (OZ) of geniculocortical neurons labeled in primary visual cortex of Fmr1^+/y (l) and Fmr1^−/y (g) mice. h Quantification of the OZ size as a percent of the dLGN. For d, h, and l, individual values for each mouse are plotted, and the bar indicates the mean