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Table 2 Sensitivity and specificity of ASD measures

From: Characterization of autism spectrum disorder and neurodevelopmental profiles in youth with XYY syndrome

Stratification

ASD (n)

Non-ASD (n)

AUC (95% CI)

Sensitivity (95% CI)

Specificity (95% CI)

ADI-R

 Full sample

9

54

0.97 (0.93–1)

1.00 (0.66–1.00)

0.87 (0.75–0.95)

 CBCL externalizing

   < 64

6

33

0.98 (0.96–1)

1.00 (0.54–1.00)

0.91 (0.76–0.98)

   ≥ 64

3

19

0.95 (0.84–1)

1.00 (0.29–1.00)

0.84 (0.60–0.97)

 CBCL internalizing

   < 64

4

32

1 (1–1)

1.00 (0.40–1.00)

0.91 (0.75–0.98)

   ≥ 64

5

20

0.93 (0.82–1)

1.00 (0.48–1.00)

0.85 (0.62–0.97)

ADOS-2

 Full sample

9

53

0.97 (0.93–1)

0.89 (0.52–1.00)

0.98 (0.90–1.00)

 CBCL externalizing

   < 64

6

32

0.99 (0.96–1)

1.00 (0.54–1.00)

1.00 (0.89–1.00)

   ≥ 64

3

19

0.92 (0.79–1)

0.67 (0.09–0.99)

0.90 (0.74–1.00)

 CBCL internalizing

   < 64

4

31

1 (1–1)

1.00 (0.40–1.00)

1.00 (0.89–1.00)

   ≥ 64

5

20

0.91 (0.79–1)

0.80 (0.28–0.99)

0.91 (0.75–1.00)

SRS-2

 Full sample

9

52

0.85 (0.75–0.96)

1.00 (0.66–1.00)

0.59 (0.45–0.73)

 CBCL externalizing

   < 64

6

33

0.92 (0.82–1)

1.00 (0.54–1.00)

0.69 (0.51–0.84)

   ≥ 64

3

19

0.72 (0.51–0.93)

1.00 (0.29–1.00)

0.42 (0.21–0.67)

 CBCL internalizing

   < 64

4

32

0.96 (0.89–1)

1.00 (0.40–1.00)

0.75 (0.57–0.89)

   ≥ 64

5

20

0.68 (0.44–0.91)

1.00 (0.48–1.00)

0.36 (0.15–0.59)

SCQ

 Full sample

9

52

0.85 (0.73–0.96)

0.78 (0.40–0.97)

0.73 (0.61–0.85)

 CBCL externalizing

   < 64

6

33

0.86 (0.72–1.00)

0.66 (0.22–0.95)

0.76 (0.58–0.89)

   ≥ 64

3

19

0.80 (0.60–1.00)

1.00 (0.29–1.00)

0.68 (0.43–0.87)

 CBCL internalizing

   < 64

4

32

0.90 (0.80–1.00)

1.00 (0.40–1.00)

0.81 (0.64–0.93)

   ≥ 64

5

20

0.77 (0.56–0.98)

0.60 (0.15–0.95)

0.60 (0.36–0.81)

  1. ASD and non-ASD DSM-5 diagnosis. AUC (area under the curve), sensitivity, and specificity refer to the comparison of the given test cut-off to the DSM-5 diagnosis