Static and dynamic postural control deficits in aging fragile X mental retardation 1 (FMR1) gene premutation carriers

Table 2 CGG repeat length, international cooperative ataxia rating scale (ICARS) scores, radiological and neurological evaluations, and clinical classification for each individual FMR1 gene premutation carriers

ID	CGG repeats	ICARS					T2 scan	Neurological exam	Clinical classification
ID	CGG repeats	Speech	Kinetic	Oculomotor	Gait and posture	Total	T2 scan	Neurological exam	Clinical classification
1	87	0	0	1	1	2	Generalized WM lesion, cerebral atropy type 1	No gait ataxia, no tremor	No FXTAS^a
2	102	0	0	1	2	3	Generalized white matter lesion; cerebral atrophy type 2	No gait ataxia, no tremor	No FXTAS
3	58	0	0	1	3	4	(−)	No gait ataxia, no tremor	No FXTAS
4	58	0	0	0	2	2	(−)	Tremor, no gait ataxia	No FXTAS
5	62	0	1	0	1	2	Mild white matter lesion, dot-like white matter hyperintensity	Tremor, no gait ataxia	No FXTAS
6	68	1	0	0	0	1	Mild white matter lesion, dot-like white matter hyperintensity	No gait ataxia, no tremor	No FXTAS
7	80	0	0	0	1	1	Mild white matter lesion, dot-like white matter hyperintensity, cerebral atrophy type 2	No gait ataxia, no tremor	No FXTAS
8	99	0	2	0	5	7	(−)	Mild gait ataxia, mild tremor	Probable FXTAS
9	107	0	1	2	5	8		Gait ataxia, tremor	Probable FXTAS
10	81	0	1	0	4	5	Cerebral atrophy type 1	Gait ataxia, tremor	Probable FXTAS
11	75	2	7	3	7	19		Gait ataxia, tremor	Probable FXTAS
12	58	0	3	0	5	8		Gait ataxia, tremor	Probable FXTAS
13	85	1	2	2	7	12	MCP sign, generalized white matter lesion; cerebral atrophy type 3	Gait ataxia, tremor	FXTAS
14	93	0	5	0	3	8	Suspected MCP sign, 4th ventricle widening, cerebral atrophy type 1, cerebellum and brainstem atrophy	Tremor, no gait ataxia	FXTAS
15	102	0	0	0	0	0			Inconclusive
16	90	0	2	2	2	6		Tremor, no gait ataxia	Inconclusive
17	64								Inconclusive
18	78						Mild white matter lesion, dot-like white matter hyperintensity		Inconclusive

11: CGG repeat length was identified from individual’s previous genetic exam at the Department of Human Genetics at Emory University School of Medicine
14: CGG repeat length was identified from individual’s previous genetic exam at the Center for Genetic Services in Corpus Christi in Taxes
(−) entry: no abnormality were identified
No entry: data were not collected
^a No FXTAS: FMR1 gene premutation carriers who currently do not how radiological and neurological signs of FXTAS

ISSN: 1866-1955