Fig. 3

Tbx1: heart and cranial nerve phenotypes. a The heart and pharyngeal arch arteries in an E10.5 WT embryo, stained for the cell-adhesion molecule PECAM/CD31 and imaged whole. b The graph indicates the % stenosis in WT, Tbx1^+/−, and LgDel embryos [73]. c A schematic the arch vasculature is provided for clarity. d Lateral view of neurofilament labeled E10.5 cranial nerves in a Tbx1^+/− embryo (CNs). e, f The ganglia of CNIX and CNX are more frequently fused or connected by axon fascicles in Tbx1^+/− than WT littermates. g CNIX/X fusion is observed at similar frequency in LgDel embryos [74]. Scale bars: 200 μm