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Fig. 6 | Journal of Neurodevelopmental Disorders

Fig. 6

From: In the line-up: deleted genes associated with DiGeorge/22q11.2 deletion syndrome: are they all suspects?

Fig. 6

Possible mechanism for 22q11.2 gene interaction. a Single causal gene; a single gene is responsible for all core 22q11DS phenotypes. b Contiguous genes; a single gene independently leads to each key 22q11DS phenotype. c Gene interactions; a combination of multiple genes are cooperatively responsible for each core 22q11DS phenotype. d Common functional targets; multiple genes conspire to disrupt key shared mechanisms, compromising key aspects of development or homeostasis at multiple 22q11DS phenotypic sites. “Individual genetic background” indicates contributions from allelic variants of genes outside the deletion region. The arrows are hypothetical illustrations of how multiple mechanisms could interact. Dotted arrows indicate weaker interactions

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