Fig. 3

Power spectral density in each ROI by clinical diagnosis. Power (log10 transformed) in each frequency band compared based on clinical diagnosis (RTT versus TD) (left panel) as well as disease stage, with active regression (n = 20) defined as experiencing a significant skill loss within 12 months of data collection and postregression (n = 29) defined as having no significant skill loss during this time period (right panel). Data are presented as individual power values with lines representing mean with standard error of the mean. To correct for multiple comparisons, a p value of 0.002 (noted by three asterisks) was used to determine significance when comparing groups by clinical diagnosis and a p value of 0.0005 (noted by four asterisks) was used when comparing groups by disease stage. a Power in the frontal ROI. b Power in the central ROI. c Power in the temporal ROI. d Power in the occipital ROI. TD typically developing, RTT Rett syndrome, AR active regression, PR postregression. Asterisks indicate significance. *p < 0.05; **p < 0.01; ***p < 0.002; ****p < 0.0005