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Table 3 Demographic characteristics and statistical analyses for participant groups: PTHS and matched AS and CdLS

From: Behavioural and psychological characteristics in Pitt-Hopkins syndrome: a comparison with Angelman and Cornelia de Lange syndromes

Demographic characteristic

PTHS, n = 24

AS, n = 24

CdLS, n = 24

Group comparison: chi-squared and Mann-Whitney U

Comparison

χ2/U

p value

Self-help scorea

Mean (SD)

4.04 (.62)

4.04 (.62)

4 (.51)

PTHS ≈ AS

288

1.00

Median (IQR)

4 (0)

4 (0)

4 (0)

PTHS ≈ CdLS

287

.967

Range

3–6

3–6

3–5

Age

Mean (SD)

11.2 (7.8)

10.9 (7.3)

11.3 (7.7)

PTHS ≈ AS

282

.901

Median (IQR)

8.5 (11)

8.5 (11)

9 (11)

PTHS ≈ CdLS

285

.951

Range

1–30

2–27

1–30

Verbal (able to speak more than 30 signs/words) (%)

2 (8.3)

0 (0)

1 (4.2)

PTHS ≈ AS

2.09

.490b

PTHS ≈ CdLS

.356

1.00b

Mobile (able to walk unaided) (%)

11 (45.8)

11 (45.8)

16 (66.7)

PTHS ≈ AS

.000

1.00

PTHS ≈ CdLS

2.12

.146

% male

50

47.8

41.7

PTHS ≈ AS

.020

.880

PTHS ≈ CdLS

.336

.560

Visiona (categorised as “normal vision”)

9 (37.5)

20 (87)

14 (60.9)

PTHS < AS

12.16

< .001

PTHS ≈ CdLS

2.57

.109

Hearinga (categorised as “normal hearing”)

23 (95.8)

24 (100)

8 (34.8)

PTHS ≈ AS

1.02

1.00b

PTHS > CdLS

19.50

< .001

  1. IQR interquartile range
  2. aDerived from the Wessex Scale [52]
  3. bFishers exact p value reported as 50% had an expected count < 5