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Table 2 Comparison between males and females on corrected intellectual functioning scores, ASD features, and maladaptive behaviours

From: Intellectual functioning and behavioural features associated with mosaicism in fragile X syndrome

 

Males

Females

p

n

Mean ± SD

n

Mean ± SD

Intellectual functioning1

 cVIQ

87

45.3 ± 23.6

36

74.1 ± 18.6

< 0.0001*

 cPIQ

88

44.7 ± 19.7

36

69.0 ± 16.9

< 0.0001*

 cWMI

34

35.8 ± 15.1

13

66.0 ± 18.6

< 0.0001*

 cPSI

46

45.1 ± 17.6

22

80.1 ± 20.0

< 0.0001*

 cFSIQ

87

33.3 ± 24.2

36

67.8 ± 17.8

< 0.0001*

ASD Features2

 ADOS CSS

80

6.54 ± 2.11

32

4.53 ± 2.29

0.090

 SA CSS

80

6.24 ± 2.25

32

4.56 ± 2.15

0.253

 RRB CSS

80

7.58 ± 1.89

32

6.16 ± 2.64

0.129

Maladaptive behaviours3

 Irritability

87

14.1 ± 11.0

34

10.1 ± 11.3

0.523

 Lethargy

87

6.22 ± 5.20

34

4.62 ± 5.41

0.829

 Stereotypy

87

5.22 ± 4.66

34

2.76 ± 4.31

0.057

 Hyperactivity

87

11.3 ± 8.23

34

6.79 ± 7.50

0.071

 Inappropriate speech

87

4.45 ± 3.51

34

2.59 ± 2.96

0.724

 Social avoidance

87

3.02 ± 2.78

34

2.38 ± 3.21

0.130

 ABC total

87

44.3 ± 28.0

34

29.2 ± 29.3

0.306

 ABC UI

87

0.64 ± 0.19

34

0.73 ± 0.20

0.415

  1. 1Semi-parametric regression adjusted for country, age and ADOS CSS
  2. 2Robust regression adjusted for country and cFSIQ3Robust Regression adjusted for cFSIQ and age
  3. *p value remained < 0.05 after adjustment for multiple testing using FDR