TY - JOUR AU - Wong, Michael PY - 2019 DA - 2019/12/16 TI - The role of glia in epilepsy, intellectual disability, and other neurodevelopmental disorders in tuberous sclerosis complex JO - Journal of Neurodevelopmental Disorders SP - 30 VL - 11 IS - 1 AB - Tuberous sclerosis complex (TSC) is a genetic disorder characterized by severe neurological manifestations, including epilepsy, intellectual disability, autism, and a range of other behavioral and psychiatric symptoms, collectively referred to as TSC-associated neuropsychiatric disorders (TAND). Various tumors and hamartomas affecting different organs are the pathological hallmarks of the disease, especially cortical tubers of the brain, but specific cellular and molecular abnormalities, such as involving the mechanistic target of rapamycin (mTOR) pathway, have been identified that also cause or contribute to neurological manifestations of TSC independent of gross structural lesions. In particular, while neurons are immediate mediators of neurological symptoms, different types of glial cells have been increasingly recognized to play important roles in the phenotypes of TSC. SN - 1866-1955 UR - https://doi.org/10.1186/s11689-019-9289-6 DO - 10.1186/s11689-019-9289-6 ID - Wong2019 ER -