|  | Cognitive | |||
---|---|---|---|---|---|
Mouse Model | Glial pathology | Epilepsy | Deficits | Other/comment | References |
Astrocytes | |||||
 Gfap-Tsc1 CKO mice | Astrogliosis/proliferation Increased astrocyte size Impaired glutamate transport, potassium channels, and gap junctions. | + | + | Not specific for astrocytes, some neuronal involvement | |
 Gfap-Tsc2 CKO mice | Astrogliosis/proliferation Increased astrocyte size Impaired glutamate transport | + | n/a | Not specific for astrocytes, some neuronal involvement | [37] |
 Gfap2-Tsc1 CKO mice | Astrogliosis/proliferation Decreased myelination | + | n/a | Not specific for astrocytes, some neuronal involvement | [38] |
 Gfap2-Tsc2 CKO mice | Astrogliosis/proliferation Decreased myelination | + | n/a | Not specific for astrocytes, some neuronal involvement | |
 Inducible GFAP-Tsc1 CKO mice | Astrogliosis/proliferation | +/− | n/a | Postnatal Tsc1 inactivation more specific for astrocytes | [41] |
Microglia | |||||
 Cx3cr1-Tsc1 CKO mice | Microglia activation Increased microglia size and number. | + | n/a | Controversial as to specificity for microglia | |
 Inducible Cxcr1-Tsc1 CKO mice | Microglia activation Increased microglia size and number | +/− | n/a | Postnatal Tsc1 inactivation more specific for microglia | |
Oligodendrocytes | |||||
 Olig2-Tsc2 CKO mice | Hypomyelination Decreased oligodendrocyte number | – | – |  | [44] |