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Table 1 Mouse models of TSC targeting glia

From: The role of glia in epilepsy, intellectual disability, and other neurodevelopmental disorders in tuberous sclerosis complex

  

Cognitive

Mouse Model

Glial pathology

Epilepsy

Deficits

Other/comment

References

Astrocytes

 Gfap-Tsc1 CKO mice

Astrogliosis/proliferation Increased astrocyte size

Impaired glutamate transport, potassium channels, and gap junctions.

+

+

Not specific for astrocytes, some neuronal involvement

[28,29,30,31,32,33,34,35,36]

 Gfap-Tsc2 CKO mice

Astrogliosis/proliferation Increased astrocyte size

Impaired glutamate transport

+

n/a

Not specific for astrocytes, some neuronal involvement

[37]

 Gfap2-Tsc1 CKO mice

Astrogliosis/proliferation

Decreased myelination

+

n/a

Not specific for astrocytes, some neuronal involvement

[38]

 Gfap2-Tsc2 CKO mice

Astrogliosis/proliferation

Decreased myelination

+

n/a

Not specific for astrocytes, some neuronal involvement

[39, 40]

 Inducible GFAP-Tsc1 CKO mice

Astrogliosis/proliferation

+/−

n/a

Postnatal Tsc1 inactivation more specific for astrocytes

[41]

Microglia

 Cx3cr1-Tsc1 CKO mice

Microglia activation

Increased microglia size and number.

+

n/a

Controversial as to specificity for microglia

[42, 43]

 Inducible Cxcr1-Tsc1 CKO mice

Microglia activation

Increased microglia size and number

+/−

n/a

Postnatal Tsc1 inactivation more specific for microglia

[42, 43]

Oligodendrocytes

 Olig2-Tsc2 CKO mice

Hypomyelination

Decreased oligodendrocyte number

–

–

 

[44]

  1. n/a not reported