Fig. 2
From: Refining the concept of GFAP toxicity in Alexander disease
Proposed model for changes in rates of synthesis and degradation of GFAP caused by the presence of mutant protein. Initially rates of synthesis and degradation are equal, with stable levels of protein. A change occurs which increases synthesis, but there is a lag period before degradation increases, during which the imbalance results in increased levels of protein. Eventually, synthesis and degradation reach a new equilibrium, but maintaining a higher level of total GFAP. Figure used with permission [18]