Fig. 3
Brain T2-weighted MRI representative of mild LTBL. Axial T2- (a–c and e–g) and T1-weighted images (d and h) in (EARS2) patient 6 with a mild disease course at 11 months (a–d) and 3 years (e–h). Note the extensive T2-hyperintense and T1-hypointense signal of the deep cerebral white matter with sparing of a periventricular rim (a, b, and d). There are also signal abnormalities in the thalami (b) and dorsal part of the midbrain (c). Note the impressive improvement 2 years later (e–h). Reprinted with permission [45]