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Fig. 4 | Journal of Neurodevelopmental Disorders

Fig. 4

From: Mitochondrial aminoacyl-tRNA synthetase disorders: an emerging group of developmental disorders of myelination

Fig. 4

Brain T2-weighted MRI representative of severe LTBL. Axial T2- (ac and eg) and T1-weighted images (d and h) in (EARS2) patient 9 at 8 months (ad) and 4 years (eh). Note the diffuse T2-hyperintense and T1-hypointense signal of the cerebral white matter, only sparing a periventricular rim (a, b, and d). There are also signal abnormalities in the thalami (b) and the midbrain (c). Three years later, there is a serious atrophy of the cerebral white matter and thalami (d, e, and h). The midbrain signal abnormalities have disappeared (f). Reprinted with permission [45].

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