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Table 3 Longitudinal mixed effects model results for effect of group (TSC+ASD and TSC-ASD) and group interactions with age on fractional anisotropy of white matter regions. Likelihood ratio tests were used to attain p values. Italicized p values indicate p < 0.05

From: Early white matter development is abnormal in tuberous sclerosis complex patients who develop autism spectrum disorder

 White matter region of interestGroupGroup × baseline ageGroup × longitudinal age
Estχ2pEstχ2pEstχ2p
LeftArcuate: waypoint to Broca’s− 0.0186.070.01− 0.0171.400.240.0061.010.32
Arcuate: Geschwind’s territory− 0.0165.620.020.0040.080.780.0040.960.33
Arcuate: Wernicke’s area− 0.02312.41<0.001− 0.0060.240.620.0051.100.30
Anterior limb internal capsule− 0.0154.420.040.010.470.490.0020.210.65
Cingulum− 0.0114.480.03− 0.0090.660.420.0020.270.61
Inferior extreme capsule− 0.0061.180.28− 0.0020.020.880.0010.030.86
Posterior limb internal capsule− 0.0091.460.23− 0.0050.140.71− 0.010.530.47
Sagittal stratum− 0.0030.100.750.0231.450.230.0040.220.64
MidlineCorpus callosum− 0.02411.66<0.001− 0.0080.390.540.0071.630.20
RightArcuate: waypoint to Broca’s− 0.02411.42<0.0010.0060.190.660.0061.560.21
Arcuate: Geschwind’s territory− 0.0040.420.520.0131.120.29− 0.0000.020.90
Arcuate: Wernicke’s area− 0.0133.970.050.0040.080.780.0020.260.61
Anterior limb internal capsule− 0.0209.220.0020.0010.010.940.0030.340.56
Cingulum− 0.0103.940.050.0000.000.990.0073.050.08
Inferior extreme capsule− 0.0020.160.690.0100.920.34− 0.0020.490.48
Posterior limb internal capsule− 0.0030.310.580.0030.060.81− 0.0020.130.72
Sagittal stratum− 0.0226.550.010.0231.780.180.03513.48<0.001
  1. Italicized p values indicate p < 0.05