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Table 4 Longitudinal mixed effects model results for effect of group (TSC+ASD and TSC-ASD) and group interactions with age on mean diffusivity of white matter regions. Likelihood ratio tests were used to attain p values. Italicized p values indicate p < 0.05. Model estimates are scaled × 1000

From: Early white matter development is abnormal in tuberous sclerosis complex patients who develop autism spectrum disorder

 White matter region of interestGroupGroup × baseline ageGroup × longitudinal age
Estimateχ2pEstimateχ2pEstimateχ2p
LeftArcuate: waypoint to Broca’s0.0110.710.400.0230.780.38− 0.0040.110.74
Arcuate: Geschwind’s territory0.0293.010.080.0522.400.12− 0.0131.430.23
Arcuate: Wernicke’s area0.0050.110.740.0150.220.64− 0.0040.170.68
Anterior limb internal capsule− 0.0090.700.400.0241.140.290.0070.710.40
Cingulum− 0.0050.460.500.0252.410.120.0020.040.84
Inferior extreme capsule− 0.0050.390.530.0201.670.200.0101.340.25
Posterior limb internal capsule− 0.0060.320.570.0251.430.230.0040.180.67
Sagittal stratum0.0040.030.850.0190.190.670.0211.640.20
MidlineCorpus callosum0.0282.970.080.0492.250.13− 0.0020.020.88
RightArcuate: waypoint to Broca’s0.0253.820.050.0020.010.93− 0.0182.580.11
Arcuate: Geschwind’s territory0.0080.240.630.0120.150.700.0020.040.84
Arcuate: Wernicke’s area0.0060.180.680.0230.610.43− 0.0030.080.78
Anterior limb internal capsule− 0.0091.070.300.0170.930.340.0060.470.49
Cingulum− 0.0070.810.370.0181.300.25− 0.0040.220.64
Inferior extreme capsule− 0.0060.720.390.0110.680.410.0122.220.14
Posterior limb internal capsule− 0.0040.230.630.0170.980.320.0060.740.39
Sagittal stratum0.0220.880.350.0450.970.32− 0.0564.170.04
  1. Italicized p values indicate p < 0.05